Author

Jia-Yi Liu

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Review Open access Sep 2026

Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design

PD-1/PD-L1 blockade can produce durable tumor control, yet primary, adaptive, and acquired resistance remain common. Existing accounts often catalogue resistance by cellular compartment, obscuring the coordinated nature of tumor adaptation. Here, we introduce immune-pressure redistribution as a treatment-oriented frame...

Xiao-Dong Wang, Jia-Yi Liu, Alifujiang Hairulajiang et al. · Molecular Cancer · 0 citations

Jul 2026

A carrier-within-a-carrier system with calcium nanoparticles encapsulated in β-cyclodextrin-polysaccharide hydrogel for verteporfin delivery and radiosensitization in orthotopic osteosarcoma.

A pH-responsive hydrogel reservoir is developed by integrating verteporfin (VP)-loaded CaCO3 nanoparticles (CaNPs) into a β-cyclodextrin-crosslinked polysaccharide hydrogel to achieve precise radiosensitization and immunomodulation, offering a promising approach to overcoming radioresistance and improving therapeutic o...

Jia-Yi Liu, Xue Tian, Alifujiang Hairulajiang et al. · Biomaterials · 0 citations