Jia-Xing Zhang

Novel mTORC1 Booster LAPTM4A Potentiates Pathological Cardiac Hypertrophy.

BACKGROUND Excessive unnecessary protein accumulation in cardiomyocyte is a leading contributor for pathological cardiac hypertrophy and has been found closely regulated by the mTORC1 (mechanistic target of rapamycin complex 1) signaling and lysosome transmembrane proteins. However, the precise regulatory mechanism str...