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Author

Jia-Xin Li

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2 papers indexed here

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Oct 2026

T-2 toxin induces glycometabolic reprogramming in chondrocytes via a MALAT1/p38‑mediated ceRNA regulatory axis.

T-2 toxin is a widely distributed dietary mycotoxin and a key environmental driver of Kashin-Beck disease (KBD), yet the molecular events linking exposure to cartilage injury remain incompletely defined. We examined the chondrotoxic mechanism of T-2 toxin through a MALAT1/miR-15b-5p/MAP2K3 competing endogenous RNA (ceR...

Chun-Qing Lu, Fang Chu, Qi Wang et al. · 0 citations
Open access Sep 2026

SIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury.

T-2 toxin, a type A trichothecene mycotoxin, has been implicated as an environmental risk factor for Kashin-Beck disease (KBD), an endemic osteoarthropathy characterized by cartilage damage. However, whether T-2 toxin impairs mitochondrial biogenesis in chondrocytes and the underlying regulatory mechanism remain unclea...

Chenxi Wang, Jun-Feng Zhou, Wei-Chang Zhang et al. · 0 citations

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