Sep 2026
A closed-loop language-model agent for target-specific multi-objective hit-to-lead optimization
Wen-Tao Cui, Li-Meng Tian, Xiao-Ning Qi et al.
· bioRxiv · 0 citations
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Sep 2026
Multi-Omics-Enabled Precision Strategies for Overcoming CAR-T Therapy Limitations in Gastrointestinal Malignancies.
Gastrointestinal malignancies, including gastric cancer, colorectal cancer, hepatocellular carcinoma, and pancreatic ductal adenocarcinoma, remain major causes of cancer-related morbidity and mortality worldwide. Although chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic m...
Ke Su, Zun-Yuan Tan, Han Li et al.
· Biofactors · 0 citations
CellRFT: Reinforcement Fine-Tuning for Single-Cell Perturbation Modeling
Predicting cellular responses to perturbations supports the study of gene function, disease mechanisms, and therapeutic strategies. Despite advances in single-cell perturbation modeling, existing models typically optimize surrogate losses that do not directly reflect the biological criteria used for evaluation, so bett...
Jie Yan, Li Liu, Han-Ze Guo et al.
· 0 citations