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Jia-Wei Zhang

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Open access Aug 2026

Exercise is associated with attenuated aging-related osteoporosis through TMAO alpha Klotho inflammasome signaling

A gut bone inflammatory framework for exercise-associated skeletal protection in aging is supported by a D-galactose aging rat model and osteoblast-like cell experiments to examine exercise-associated changes in trimethylamine N-oxide (TMAO) and inflammasome signaling.

Lihua Zhang, Xiaoyu Huang, Jia-Wei Zhang et al. · iScience · 0 citations

Open access Aug 2026

Spatial multi omic profiling maps hypoxia-driven pro-fibrotic SPP1+ macrophages underpinning immune escape and TACE resistance in hepatocellular carcinoma

An integrative spatial multi-omics strategy, combining bulk and single-cell RNA sequencing, subcellular-resolution spatial transcriptomics, and spatial proteomics on tissues from TACE-treated and treatment-naïve HCC patients, presents a potential therapeutic strategy to overcome TACE resistance and improve clinical out...

Fansen Ji, Hao Chen, Boyang Wu et al. · Experimental Hematology & On... · 0 citations