Author

Jia-Wei Chen

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Open access Aug 2026

CUDC-907 attenuates pulmonary fibrosis by reversing HDAC1-mediated SMAD4 deacetylation at lysine 45

These findings identify SMAD4 K45 acetylation as a critical molecular switch in fibrogenesis and position CUDC-907 as a promising epigenetic strategy for the treatment of fibrotic lung diseases.

Yu Li, Yuan Cui, Hao-Yu Qiu et al. · Biology Direct · 0 citations