The mechano-immunological barrier in fibrosis-associated lung cancer: targeting matrix stiffness and the Piezo1 axis for microenvironment normalization
This review summarizes the Piezo1-mediated mechanotransduction networks involved in the fibrosis-to-cancer transition and discusses emerging “mechano-immunotherapeutics,” including targeted Piezo1 modulators, precision nanodelivery systems, and ECM-normalizing agents (e.g., LOX inhibitors and losartan).