Author

Jia Tang

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Open access Oct 2026

Acute respiratory distress syndrome FXR/Sptlc2 signaling promotes alveolar macrophage mitophagy and limits lung inflammation.

Alveolar macrophages (AMs) undergo functional reprogramming that critically regulates lung inflammation. Although mitophagy is essential for mitochondrial quality control, its role in macrophage functional reprogramming during acute respiratory distress syndrome (ARDS) remains unclear. Here, we identify the nuclear rec...

Mi Yan, Yan-Fei Liu, Meng-Zhao Deng et al. · Cell Reports · 0 citations

Open access Sep 2026

IGF‐1/SLC25A33 Maintains Blood‐Labyrinth Barrier Integrity by Suppressing TGF‐β/Smad2‐Mediated Pericyte Activation in Age‐Related Hearing Loss

ABSTRACT Age‐related hearing loss (ARHL) is a prevalent sensory disorder in the elderly, yet the molecular mechanisms underlying cochlear aging remain incompletely understood. While insulin‐like growth factor 1 (IGF‐1) has been implicated in ARHL, its role in the stria vascularis, particularly in pericyte‐mediated bloo...

Rui Xu, Jia Tang, Huan Lin et al. · Aging Cell · 0 citations