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Author

Jia-Shu Han

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Review Sep 2026

T-Cell Exhaustion and Senescence in Cancer: Regulatory Circuits and Therapeutic State Engineering.

In cancer, T-cell state strongly influences antitumor immunity and response to immunotherapy. High-parameter cytometry, single-cell transcriptomics, and multiomic profiling now resolve lineage identity, differentiation history, clonality, metabolic fitness, and tissue adaptation in parallel. These studies place naïve,...

Jia-Shu Han, Xiaohong Lyu, Mengwei Wu et al. · 0 citations

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