Overcoming the blood-brain barrier for therapeutics targeting neurodegenerative diseases: a patent review (2020-present).
INTRODUCTION The blood-brain barrier (BBB) restricts drug entry into the CNS, with most therapeutics showing < 1% brain penetration, limiting efficacy in neurodegenerative diseases. AREAS COVERED Patents (2020-2026) were retrieved from SciFinder, Web of Science, PubMed, and Reaxys using combinations of 'blood-brain b...