Author

Jia-Ni Liu

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Review Open access Oct 2026

Mitochondrial regulation of tumor-associated macrophage function

Tumor-associated macrophages (TAMs) adapt to hypoxia, nutrient competition, lipid accumulation, and anticancer treatment. Mitochondria contribute to this adaptation through energy metabolism, redox signaling, mitochondrial DNA (mtDNA) sensing, and metabolite-dependent regulation of gene expression. This Review examines...

Jia-Bao Xu, Yong-Tao Liu, Hong-Jie Zhang et al. · Frontiers in Immunology · 0 citations

Open access Jan 2026

From Germline Variants to Tumor Outcome: GWAS‐Based Functional Genomics Prioritizes Colorectal Cancer Susceptibility Genes and Links SMAD9 to Prognosis

Integrating statistical genetics, regulatory prediction, and locus‐directed experiments prioritized SMAD9, MAP3K2, FADS1, and ACTR1B as CRC susceptibility genes, and placed experimental bounds on the proposed MAP3K2 and ACTR1B mechanisms.

Chengguang Hu, Guang Yang, Han Xiong et al. · Human Mutation · 0 citations