Author

Jia-Ni C. Yin

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Open access Oct 2026

Detection of an EGFR L858R mutation following prolonged sequential ALK-TKI therapy in ALK-rearranged NSCLC: a case report

Anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer (NSCLC) typically exhibits profound sensitivity to ALK tyrosine kinase inhibitors (TKIs). While sequential therapy with next-generation inhibitors has significantly improved long-term outcomes, acquired resistance remains an eventual challen...

Jun-Yue Deng, Juan Li, Yu-Hong Chen et al. · Journal of Cancer Research a... · 0 citations

Open access Aug 2026

Prognostic significance of positive margin-informed tumor status in esophageal squamous cell carcinoma using next-generation sequencing

Abstract Background Reliable prognostic biomarkers are urgently needed for operable esophageal squamous cell carcinoma (ESCC), as conventional histopathology often fails to detect minimal residual disease and accurately predict patient outcomes. Patients and Methods This study investigated the mutational patterns in ES...

Di Lu, Yu Tong, Chun-Hong He et al. · The Oncologist · 0 citations

Open access Aug 2026

Paired genomic profiling of primary tumor and lymph-node metastases identifies candidate prognostic features in penile squamous cell carcinoma

Recurrent CCND1/FGF19-containing 11q13 amplification, TCR pathway alterations, TCR pathway alterations, and elevated metastatic TMB warrant evaluation as potential prognostic features in larger, independently validated cohorts with integrated HPV and immune profiling.

K. Lou, Ling-Hui Liang, Hong-Zhou Cai et al. · The Oncologist · 0 citations