Open access
Sep 2026
AURKA phosphorylation licenses TRIM28-dependent SUMOylation to stabilize SPICE1 in prostate cancer bone metastasis
Bone metastasis is a major cause of disease progression and cancer-related death in advanced prostate cancer (PC). Although spindle and centriole associated protein 1 (SPICE1) has been implicated in tumor biology, its role in PC metastasis and its post-translational regulation remain largely unknown. SPICE1 expression...
Hao-Xin Jiang, Wei-Lai Tong, Shi-Jiang Wang et al.
· Cellular and Molecular Life... · 0 citations