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Jia-Min Yi

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Sep 2026

Spatial control of mitochondrial ubiquitination by the AMBRA1-RMC1-HUWE1 axis.

Mitochondrial ubiquitination is a central component of mitochondrial quality control. The PINK1 (PTEN induced kinase 1)-PRKN (parkin RBR E3 ubiquitin protein ligase) pathway established how loss of mitochondrial membrane potential can trigger a phospho-ubiquitin feed-forward cascade on the outer mitochondrial membrane...

Jia-Min Yi, Xin Yong, Da Jia · 0 citations
Open access Jul 2026

HUWE1 targets mitochondria via RMC1 to promote neurodevelopment.

An AMBRA1-RMC1-HUWE1 signaling axis that directs HUWE1-mediated ubiquitination to mitochondria to regulate neural development is identified and mitochondrial quality-control enhancement as a potential therapeutic strategy is suggested.

Jia-Min Yi, Qin Yang, Chun Zhou et al. · 1 citation

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