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Author

Jia-Meng Gao

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Open access Jul 2026

IRF1-mediated sensing of oxidized mitochondrial DNA drives macrophage PANoptosis in lung ischemia–reperfusion injury

Lung ischemia–reperfusion injury (IRI), a significant factor contributing to early mortality following lung transplantation (LTx), is driven by molecular mechanisms that are not yet fully understood. In this study, we elucidate a crucial signaling pathway initiated by extracellular histones (ex-His), which connects mit...

Nan Zhang, Zhiyuan Zhang, Jing Yu et al. · 0 citations

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