IRF1-mediated sensing of oxidized mitochondrial DNA drives macrophage PANoptosis in lung ischemia–reperfusion injury
Lung ischemia–reperfusion injury (IRI), a significant factor contributing to early mortality following lung transplantation (LTx), is driven by molecular mechanisms that are not yet fully understood. In this study, we elucidate a crucial signaling pathway initiated by extracellular histones (ex-His), which connects mit...