Gastric cancer (GC) development follows a sequential and complex pathophysiological process known as Correa’s cascade, progressing from chronic gastritis (active or inactive) to precancerous lesions (intestinal metaplasia (IM) and dysplasia) and ultimately to adenocarcinoma. Current GC therapies have limited efficacy...
Ting-Yao Wang, Fu-Ming Yao, Rui-Lin Li et al.· Frontiers in Pharmacology· 0 citations
ABSTRACT Cancer remains a major global health burden despite recent advances in early diagnosis and novel therapeutics. The cytoskeleton is a dynamic filamentous network that controls cell morphology, motility, and intracellular trafficking; in normal cells, its activity is tightly regulated, whereas in cancer, it unde...
Jie Chen, Wen-Xin Yang, Yong-Han Song et al.· MedComm· 0 citations
It is elucidated that IL-23 upregulates METTL16, which in turn enhances PD-L1 expression and facilitates tumor immune escape, which establishes the IL-23/METTL16/PD-L1 axis as a novel regulatory pathway and potential therapeutic target in cancer immunotherapy.
Xue-Shan Pan, Yue Wang, Jing-Jing Luo et al.· American Journal of Cancer R...· 1 citation
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