Open access
Oct 2026
PLA2G4A-driven arachidonic acid metabolic reprogramming promotes NSCLC progression via the HSF1 signaling axis
Aberrant arachidonic acid (AA) metabolism is a hallmark of cancer, and cytosolic phospholipase A2 (PLA2G4A) is the rate-limiting enzyme that initiates this cascade. However, the cell-intrinsic role of PLA2G4A and its downstream signaling mechanisms in non-small cell lung cancer (NSCLC) remain poorly understood. Her...
Wei-Fang Wang, Ze Wang, Kun-Fang Li et al.
· Cell Death Discovery · 0 citations