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Author

Jialong Qi

2 papers indexed here

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Review Open access Sep 2026

SLC25 in intestinal inflammation: mechanisms, pathological roles, and therapeutic implications

Inflammatory bowel diseases (IBD) represent a spectrum of chronic gastrointestinal disorders fueled by a complex multifactorial interplay, where mitochondrial dysfunction has emerged as a critical contributor. The SLC25 family of mitochondrial transporters mediates the exchange of essential metabolites across the mitoc...

Juan Xu, Zan Zuo, Pei-Lin Wang et al. · 0 citations
Open access Jul 2026

Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.

This work unveils POLRMT as a metabolic gatekeeper that licenses CSC plasticity through KDM6B-α-KG/H3K27me3-mediated chromatin remodeling, proposing the mitochondrial transcription machinery as a therapeutic target for dismantling the CSC hierarchy in CRC.

Lei Tang, Siheng Nie, Jia-Long Qi et al. · 0 citations

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