Neuroimmune crosstalk in pancreatic ductal adenocarcinoma: integrating neuroscience and immuno-oncology.
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and remains largely refractory to immunotherapy because of its profoundly immunosuppressive tumor microenvironment (TME). Emerging advances in cancer neuroscience suggest that immune resistance in PDAC may not be fully explained by immune-cen...