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Open access Oct 2026

Functional Nucleic Acid-Antibody Conjugates for Effective Tumor Targeted Therapy With Controllable Side Effects.

Antibody-guided therapeutics, including antibody-drug conjugates and radiopharmaceuticals, efficiently deliver payloads to tumor lesions, but the weeks-long half-life of antibodies promotes accumulation in normal tissues, increasing the risk of off-target toxicity. Although conventional linkers generally provide system...

Jia Liu, Zhi-Qiang Ren, Yuanmeijing Hu et al. · 0 citations
Review Open access Sep 2026

Nucleic acid aptamers: new methods for selection, target validation, molecular diagnostics and therapeutics

Nucleic acid aptamers, often referred to as “chemical antibodies,” are versatile, specific, and easily modifiable functional nucleic acids. There is a growing focus on new methods for the selection and target validation of aptamers, with the aim of expanding their biomedical applications in molecular diagnostics and th...

Ding-Kun Ji, Hao-Zhi Lei, Jia Liu et al. · 0 citations

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