External memory lets language-model agents answer questions about histories too long for the answer model's context window. Updates create a harder problem than retrieving a recent fact: changing one relation can redirect a multi-hop question to records about an entity absent from the question. We study this update-dep...
Zhi Song, Ximing Xing, Chun-Han Li et al.· 0 citations
Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces. Here we show that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological...
Zhen-Chao Tang, Xiaogang Xu, Tian-Xu Lv et al.· 0 citations
Biomolecular binder design for peptides and antibodies requires generating diverse candidates that satisfy stringent three-dimensional geometric constraints while enabling affinity-oriented exploration under strong structural priors. In current generative models, the effective search space for structurally feasible bin...
Zhihua Tian, Jiale Zhou, Rubo Wang et al.· Proceedings of the 32nd ACM...· 0 citations
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