Author

Jia-Le Chen

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Review Open access Oct 2026

Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease

Membrane contact sites (MCSs) are specialized, non-fusogenic interfaces that allow organelles to exchange ions, lipids, metabolites and stress signals. These contacts support adaptation to nutrient, proteotoxic and inflammatory stress. However, persistent or misregulated organelle communication can redirect metabol...

Ya-Qin Hou, Da-Chen Luo, Jia-Le Chen et al. · Cell Communication and Signa... · 0 citations

Oct 2026

Multi-omics analysis reveals oxidative stress-associated alterations in glycerophospholipid metabolism and inflammatory response in 6PPDQ-exposed macrophages.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPDQ), a transformation product of the tire antioxidant 6PPD, is an emerging environmental contaminant with increasing toxicological concern. While macrophages are critical in recognizing and managing chemical stress, how 6PPDQ exposure perturbs their innate...

Wen-Jie Zhang, Jia-Le Chen, Qi Wang et al. · Environmental Pollution · 0 citations