Sep 2026
Chronic Ileitis Ameliorates Hyperglycemia via a 3-HB/NKX6.1 Axis in Mice.
A novel gut-islet axis where microbiota-derived 3-HB preserves β-cell functional identity via HCAR2 dependent regulation of NKX6.1 is identified, offering a potential therapeutic strategy for type 2 diabetes.
Yi Fang, Chang Zheng, Ping Jiang et al.
· Molecular and Cellular Endoc... · 0 citations