Jia-Jing Cai

Design, synthesis and evaluation of fluorinated CYP1B1 inhibitors based on a trans-stilbene scaffold.

Cytochrome P450 1B1 (CYP1B1) is selectively overexpressed in various tumor cells and plays a critical role in the metabolic inactivation of chemotherapeutic agents, leading to drug resistance. Therefore, the development of selective CYP1B1 inhibitors represents a promising strategy to overcome chemoresistance. In this...