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Author

Jiajie Feng

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Review Oct 2026

The ATG4 family: Molecular gatekeepers of autophagic flux and emerging targets for disease intervention.

Autophagy represents an evolutionarily conserved intracellular degradation pathway. Aberrant activation or impaired autophagic flux contributes substantially to the pathogenesis and progression of numerous human diseases, such as tumors and neurological disorders. As the only cysteine proteases within the core autophag...

Dan Mu, Xiong Pei, Jia-Jie Feng et al. · 0 citations
Review Open access Jul 2026

Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies

This review systematically summarizes the molecular mechanisms underlying LMP initiation and execution, as well as the regulatory pathways of LDCD modalities, including apoptosis, necroptosis, ferroptosis, pyroptosis, immunogenic cell death, and autophagy-dependent death.

Yang Li, Jiajie Feng, Xinzhu Dong et al. · 1 citation

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