Author

Jia-Hui Guo

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Review Open access Sep 2026

Overcoming Resistance to PARP Inhibitors in BRCA-Mutated Cancers: Mechanisms and Therapeutic Strategies

The tumor suppressor genes BRCA1 and BRCA2 are essential for homologous recombination (HR) repair. Mutations in BRCA1/2 compromise HR repair efficacy, resulting in heightened susceptibility of tumor cells to poly (ADP-ribose) polymerase inhibitors (PARPi) via synthetic lethality. To date, several PARPi have been approv...

Jia-Hui Guo, Yi-Lei Wang, Jie Li et al. · Journal of Cancer · 0 citations

Review Open access Jul 2026

Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control

This review comprehensively evaluates the rational design of classical animal herpesvirus vectors, including pseudorabies virus, herpesvirus of turkeys, and feline herpesvirus type 1, providing perspectives on how continuous biotechnological innovations will empower herpesvirus vectors to serve as formidable prophylact...

Jia-Hui Guo, Chen Mei, Xin-Yao Sun et al. · Frontiers in Microbiology · 0 citations