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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jia-Hong Lu

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Open access Oct 2026

The R2TP Complex Couples mTORC1 Signaling to Vacuolar ATPase Assembly and Lysosomal Function

The vacuolar ATPase (V‐ATPase) is essential for lysosomal acidification and autophagy, and its activity is regulated by nutrient‐sensitive reversible assembly of its V1 and Vo domains. While mTORC1 is known to inhibit V‐ATPase assembly, the precise molecular mechanisms remain incompletely understood. Here, using TurboI...

Xiao-Wen Zhang, Ming-Yue Wu, Qi Zhu et al. · 0 citations
Aug 2026

Titanium dioxide nanoparticles induce neurotoxicity through PI3K/Akt-mediated mitochondrial apoptosis.

Concerns about chronic exposure to titanium dioxide nanoparticles (TiO2-NPs) have increased because of their widespread use in consumer products and subsequent environmental release. Previous studies have shown that TiO2-NPs exert neurotoxic effects and may contribute to Parkinson's disease (PD)-related neurodegenerati...

Zhi-Bing Zhang, Yanyan Fang, Shuang Chen et al. · 1 citation
Open access Aug 2026

Proteome stability and dynamic protein complex profiling identified EEF1A1 as a novel translation regulator of autophagy and mitophagy

This work integrates thermal proteome profiling with co-aggregation analysis to monitor protein thermal stability and complex assembly dynamics in response to two canonical inducers: Torin 1, which activates autophagy via mTOR inhibition, and CCCP, a mitochondrial uncoupler that triggers mitophagy.

Shuang Zhang, Ya Zeng, Feng-Ming Li et al. · 0 citations

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