Integrin-β1/FAK signaling is involved in electrical stimulation to prevent disuse muscular atrophy induced by tail suspension in mice.
Electrical stimulation upregulates the expression of the mechanosensor integrin β1 and enhances the phosphorylation of its downstream effector, FAK, in skeletal muscle, providing preclinical evidence supporting the role of the integrin-β1/FAK signaling pathway in electrical stimulation-mediated muscle preservation.