Drimane-type sesquiterpenoids from aspergillus keveioides under OSMAC strategy characterized by GNPS possess in vitro antitumor cytotoxicity: A combined approach of bioactivity assay and network pharmacology.
Guided by LC-MS/MS and Global Natural Products Social Molecular Networking (GNPS), two new drimane-type sesquiterpenoids, ustusolates H and I, along with eleven known analogues, were isolated from the fermentation broth of Aspergillus keveioides. Their chemical structures were elucidated on the basis of comprehensive s...