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Review Open access Oct 2026

Organelle-Targeted Nanocarriers for Cancer Therapy: Design Principles, Intracellular Trafficking, and Translational Barriers in Precision Drug Delivery

Abstract The clinical translation of cancer nanomedicine remains constrained by inefficient intracellular delivery, poor subcellular specificity, and limited tumor accumulation, highlighting the need for more precise drug delivery strategies. Organelle-targeted nanocarriers have emerged as a promising platform for enha...

Han-Gen Zhang, Jia Guo, Xin-Miao Wang et al. · 0 citations
Open access Aug 2026

MOLECULAR BASIS FOR PINK1 MATURATION

A general mechanism for PINK1 recognition by the HSP90α/CDC37/FKBP51 chaperone complex is revealed and a potential approach for upregulating PINK1 activity, which is impaired in PD is suggested.

Junrong Xue, Huiqin Xu, Yanfeng Zhang et al. · 0 citations

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