Sep 2026
A TMEM119-tankyrase axis restrains microglial phagocytosis to maintain memory and enables pharmacological forgetting.
The persistence or loss of memory depends on the stability of synaptic connections. Microglia regulate this stability in part by phagocytic elimination of synapses, while the molecular mechanism that sets their intrinsic phagocytic capacity at homeostasis remains unknown. Here, we show that TMEM119, a microglia-specifi...
Su-Hua Sun, Chen-Feng Wang, Yang Bian et al.
· Neuron · 0 citations