Author

Jia Cheng

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Oct 2026

Discovery of a novel BRD4 inhibitor for the treatment of acute myeloid leukemia.

Bromodomain-containing protein 4 (BRD4), an epigenetic regulatory reader, is closely related to the development of various cancers, so it has emerged as one of the most extensively investigated therapeutic targets for tumors. However, no BRD4 inhibitors have received clinical approval to date, underscoring the signific...

Yi-Sheng Li, Jing-Ying Liu, Jia Cheng et al. · Bioorganic chemistry (Print) · 0 citations

Review Open access Aug 2026

Interconnected roles of cellular senescence and the immune microenvironment in tumor progression: from pan-cancer mechanisms to glioblastoma implications

This review systematically examines the molecular mechanisms of cellular senescence, with emphasis on the intrinsic logic governing bidirectional remodeling between senescent cells and the immune microenvironment, to provide a new theoretical foundation for next-generation precision cancer immunotherapy.

Wen-Wen Zhao, Pengfei Zhang, Li-Xin Li et al. · Cell Death Discovery · 0 citations