Sep 2026
Structure-Guided Design, Synthesis, and Evaluation of Novel 6-Methoxyquinoline-4-carboxamide Derivatives as First-in-Class Nano-Molar B3GAT3 Inhibitors for the Treatment of Hepatocellular Carcinoma
TMLB-G9 is a promising B3GAT3 inhibitor worthy of further development for HCC therapy and exhibits superior anti-HCC activity to TMLB-C16 in two HCC xenograft models.
Hao Yin, Xiao-Wen Yan, Bo Fan et al.
· Journal of Medicinal Chemist... · 0 citations