Jia-Can Su

Genome-wide association studies of osteoarthritis: from genetic discovery to precision medicine.

Osteoarthritis (OA) affects more than 500 million people worldwide, yet disease-modifying therapies remain unavailable. Genome-wide association studies (GWAS) have transformed understanding of OA genetic susceptibility, progressing from early single-cohort analyses to multi-ancestry meta-analyses involving 2 million in...

Decoding mechanoregulation in immunological synapses using biomimetic artificial cells

Rapid discovery of monoclonal antibodies via high-throughput single BCR affinity sequencing

Antigen Affinity BCR-seq is presented, a high-throughput single-cell sequencing platform that can obtain the relative antibody–antigen affinity of thousands of paired native BCR sequences and potentially provides large-scale sequence-affinity datasets for machine learning-driven therapeutic antibody design and developm...

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

This work established miR‐197‐3p as a novel therapeutic regulator in OA and introduced a bioinstructive, injectable, and cell‐free strategy that integrates miRNA therapy and redox modulation for disease modification and cartilage regeneration.