Author

Jiabo Ding

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Open access Aug 2026

A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival

ABSTRACT For Brucella spp., the ability to invade and survive within host macrophages is essential for causing chronic infections in their mammalian hosts. In this study, a genome-wide CRISPR knockout screen was performed for the first time in human THP-1 macrophages to identify host genes mediating resistance to Bruce...

Xinhui Wang, Sujun Wu, Yi-Ge Ding et al. · Emerging Microbes and Infect... · 0 citations

Open access Aug 2026

Brucella deploys multiple type IV effectors that simultaneously control bacterial survival and host inflammatory cell death

ABSTRACT The type IV secretion system (T4SS) acts as the central virulence determinant of Brucella, facilitating intracellular survival via the secretion of effector proteins. In this study, we combined bioinformatic prediction with translocation assays to identify seven novel VirB-dependent effectors. Functional chara...

Dongjie Sun, Meng-Tao Zhang, Yifan Wu et al. · Virulence · 0 citations

Open access Aug 2026

Development, Characterization, and Validation of an MS2 Phage-Based Armored RNA Control for Schmallenberg Virus Detection

Schmallenberg virus (SBV) is a transboundary animal pathogen that causes reproductive disorders in ruminants, necessitating standardized molecular surveillance. Adhering to the Chinese national standard GB/T 43159—2023, we developed armored RNA quality control materials using MS2 bacteriophage technology targeting the...

Meng-Qi Zhao, Yi-Bo Wang, Yifei Xie et al. · Pathogens · 0 citations