ABSTRACT Neurotropic coronaviruses can invade the central nervous system (CNS) and cause severe neurological disease, but the mechanisms underlying virus-induced neuroinflammation remain incompletely understood. Here, we report that infection with porcine hemagglutinating encephalomyelitis virus (PHEV), a neurotropic b...
The STING pathway is pivotal in defense against RNA viruses; however, its involvement in swine acute diarrhea syndrome coronavirus (SADS-CoV) infection remains unclear. This study reveals a dual mechanism where in SADS-CoV triggers STING activation via nuclear envelope rupture but subsequently evades immunity through i...
Young pigs are more susceptible to PRV and the infection in piglets is nearly 100% fatal, whereas adult pigs exhibit reproductive disorders such as abortion, stillbirths, and reduced fertility, ultimately decreasing farm productivity.
Yu-Lan Jin, Xuan Ji, Weiren Dong et al.· Journal of Zhejiang Universi...· 0 citations
This study establishes a reverse genetics platform for an emerging G2c PEDV strain and provides a stable fluorescent reporter virus, offering valuable tools for visualizing viral infection and investigating virus–host interactions.
Fan Zhang, He-Lu Liu, Linlong Ji et al.· Viruses· 0 citations
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