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Author

Ji-Ye-On Lee

3 papers indexed here

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Aug 2026

Sauchinone-loaded chitosan nanoparticles simultaneously suppress NF-κB-driven inflammation, activate the Nrf2/HO-1 axis, and restore sarcolemmal utrophin in a murine model of Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is driven by dystrophin loss, chronic NF-κB-dependent inflammation, impaired Nrf2 antioxidant signaling, and dystrophin-associated protein complex (DAPC) instability. Sauchinone has dual NF-κB-inhibitory and Nrf2-activating activity but poor oral bioavailability (<8%). We prepared sauc...

Jae Ho Shim, Ji-Ye-On Lee, Jih-Ye Han et al. · 0 citations
Open access Aug 2026

DGAT1 regulates macrophage pyroptosis during Klebsiella pneumoniae infection

Klebsiella pneumoniae (Kp) is a Gram-negative opportunistic pathogen that causes severe infections, including pneumonia and sepsis, yet the molecular mechanisms governing macrophage cell death during Kp infection are incompletely understood. Here, we identify diacylglycerol acyltransferase-1 (DGAT1) as a critical...

Hui-Jung Jung, S. Jeong, Sang-Hee Lee et al. · 0 citations

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