Open access
Sep 2026
Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming
ABSTRACT Glioblastoma (GBM) is a lethal malignancy characterized by therapeutic resistance and recurrence, which are driven by dynamic cellular metabolic adaptation within the tumor microenvironment. However, the precise molecular metabolic mechanisms remain poorly understood. Here, we found that palmitic acid (PA) acc...
Zi-Jie Gao, Rong-Rong Zhao, Zhe-Yuan Chen et al.
· Advancement of science · 0 citations