Author

Ji Sun Park

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Open access Sep 2026

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

A synthetic ionizable lipid with a dual pKa property that is retained in formulated LNPs is introduced and it is shown that after intravenous injection, these dual pKa LNPs produce lung‐selective mRNA expression with higher potency than a cationic lipid‐rich comparator while remaining well tolerated.

Seong Gi Lim, Min-Ju Lee, Yiming Wang et al. · Advancement of science · 0 citations

Aug 2026

Photochemistry-Based Development of Ionizable Lipid Library for mRNA-Lipid Nanoparticle Delivery In Vivo.

A photochemistry-based ionizable lipid library (PILL) platform that enables the rapid discovery of ionizable lipids for mRNA delivery and provides a versatile framework for the development of next-generation LNP systems for nucleic acid therapeutics is reported.

Simin Chun, Hyorim Nam, Donghyun Lee et al. · Journal of the American Chem... · 0 citations