Ji-Lin Chen

Cytoskeletal and phagolysosomal failure in macrophage antibacterial immunity: the PRRSV–porcine alveolar macrophage axis as a natural-host model

Viral infection of professional phagocytes can compromise antibacterial immunity because the cellular machinery reshaped for viral replication and immune evasion overlaps with the machinery required for bacterial capture, intracellular killing, and inflammatory signaling. Phagocyte cell biology has defined core cytos...