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Open access Sep 2026

Integrative bioinformatics and machine learning reveal hub genes and immune signatures bridging type 2 diabetes mellitus, fracture susceptibility, and osteoblast differentiation dysfunction

To investigate the causal relationship between type 2 diabetes mellitus (T2DM) and fracture and identify molecular targets linking T2DM to impaired osteogenesis, we performed two-sample Mendelian randomization (MR) using large-scale GWAS data, followed by integrated bioinformatic and machine learning analyses of T2DM-,...

Shu-Long Sun, Qian Chen, Hua Li et al. · 0 citations
Open access Sep 2026

Multi-omics integration reveals macrophage polarization and ferroptosis as key mechanisms underlying kaempferol’s therapeutic efficacy in peripheral artery disease

Multi-omics and experimental findings uncover macrophage polarization and ferroptosis modulation as central mechanisms mediating kaempferol’s therapeutic efficacy in PAD, providing mechanistic insights and potential molecular targets for precision intervention.

Zi-Jun Qiao, Miao-Miao Wang, Wang-Sheng Luo et al. · 0 citations

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