Bovine coronavirus (BCoV), a primary etiological agent of calf diarrhea, exhibits dual tropism for the respiratory and enteric tracts. However, research on BCoV gene function and pathogenesis has been limited by the lack of convenient and flexible reverse genetics tools. Herein, we report a robust reverse genetics syst...
Yi-Ran Zeng, Han Gao, Yuan-Lu Lu et al.· Veterinary Research· 0 citations
It is indicated that spike protein mutations are involved in the attenuation of GVI-1 IBV strains, and insights into the molecular basis of IBV attenuation during serial passage are provided.
A chimeric subunit vaccine, RBD-HA, in which the receptor-binding domain of the QX-type IBV spike protein replaced the immunodominant head domain of H9N2 AIV haemagglutinin is developed, providing proof of concept for a bivalent subunit vaccine targeting two major avian respiratory viruses.
This study is the first to identify circ-INSR as a host factor contributing to influenza virus replication, and provides a basis for developing circRNA-based strategies against H9N2 avian influenza virus.
These findings establish ckATP1A1-AS1 as a key antiviral lncRNA that restricts IAV replication by coordinating innate immune signaling and directly targeting several steps in the viral replication cycle.
Meng-Lu Fan, Zhi-Yuan Liu, Lu-Lu Deng et al.· Journal of Virology· 0 citations
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