Ji-Guang Yang

Integrated single-cell and bulk transcriptomic analysis identifies a novel senescent fibroblast subtype associated with poor prognosis in acral melanoma

Highlights • A high-resolution single-cell atlas of acral melanoma was constructed, revealing 10 major cell types and 16 melanoma subpopulations.• A novel senescent fibroblast subtype (sCAF_CDKN2A) was identified as a key driver of poor prognosis in acral melanoma.• SEMA6A, KIT, COL3A1, and VCAN were identified and val...