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Author

Jessica Sims

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Open access Sep 2026

Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (Mtb) is responsible for more deaths per year than any other infectious disease. Resistance of circulating Mtb to the standard of care treatment regimen is an urgent global health crisis for which novel antibiotic treatments are needed. We have developed extremely potent, orally bioavailabl...

Eric M. Kofoed, Terry D. Crawford, Christine M. Bowman et al. · 0 citations
Review Sep 2026

Safety Lessons for YAP/TAZ-TEAD Inhibition: From Mechanism to Translation.

The human Hippo pathway restricts tissue growth primarily through mammalian Ste20-like kinase 1/2 (MST1/2) and large tumor suppressor 1/2 (LATS1/2)-mediated regulation of transcriptional activators Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ). When this brake is lifted, nuclear...

Sayantanee Paul, Jessica Sims, Anwesha Dey · 1 citation
Open access Aug 2026

Preclinical Characterization of Hippo pathway inhibition: Insights from Pharmacological and Genetic Studies

The Hippo pathway is an evolutionarily conserved regulator of growth, regeneration, and organ homeostasis, and while its dysregulation is well established in cancer, the effects of inhibiting this pathway on normal tissues are less understood. Here we have systematically investigated the impact of Hippo pathway inhibit...

Sayantanee Paul, Michelle Lepherd, Thijs J. Hagenbeek et al. · 0 citations

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