Jessica M. J. Swanson

Asymmetry and Allostery: Insights into the Mechanism of Directional Peptide Translocation in AAA+ Unfoldases

All-atom molecular dynamics simulations of AAA+ unfoldases suggest that structural asymmetry creates position-dependent allosteric interactions that generate kinetic asymmetry, biasing a fundamentally stochastic ATPase cycle toward directional substrate translocation while still permitting variation in stepping behavio...