Author

Jessica E. Thaxton

2 papers indexed here

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Open access Oct 2026

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

Tumor-associated macrophages (TAMs) promote tumor growth, inhibit effector lymphocytes, and induce resistance to immune checkpoint inhibitors (ICI). Therapies designed to deplete TAMs have had little success in the clinic, and strategies aimed to repolarize immunosuppressive TAMs to pro-inflammatory states have struggl...

Matthew P. Zimmerman, Vasyl Zhabotynsky, Hai-Yang Wang et al. · bioRxiv · 0 citations

Open access Sep 2026

Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4+ TH17 Cells

The differentiation of naïve CD4+ T cells into effector T cell subsets such as TH1, TH2, TH17 and TREG cells is governed by tightly coordinated activation programmes dependent on T cell receptor (TCR) engagement, co-stimulation, and cytokine signalling. This differentiation process involves regulation of stress-respons...

Priyadarshini Chatterjee, Keishla Sánchez Ortiz, Stanislav Dikiy et al. · bioRxiv · 0 citations