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Author

Jessica Bertrand

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Open access Sep 2026

Differential regulation of SOCS signalling and immunoproteasome pathways by JAK inhibitors and TNF inhibitors in rheumatoid arthritis

Janus kinase (JAK) inhibitors and TNF inhibitors (TNFi) are established therapies in rheumatoid arthritis (RA), yet their differential effects on the JAK/STAT/SOCS/proteasome axis remain incompletely understood. This pilot study systematically characterised treatment-specific effects of baricitinib, tofacitinib, and TN...

K. Ghannam, Linh Nguyen My, Christine Behrendt et al. · 0 citations
Open access Aug 2026

Genetic and population analyses implicate thyroid-related regulation of RNF144B in chondrocalcinosis.

These findings identify genetic loci for radiographic chondrocalcinosis and offer hypothesis-generating evidence of thyroid-related pathways in its susceptibility, providing insight into molecular mechanisms underlying joint mineralization.

Ya-Hong Wu, Yan-Ning Xu, P. Okoro et al. · 0 citations

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