Author

Jesse Gillis

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Open access Sep 2026

Neuronal and vascular genome-maintenance states organize opposing multicellular architectures in the aging brain

Genome maintenance is predominantly studied as a cell-intrinsic process, although its consequences can extend to tissue aging. Brain aging is characterized by region-specific changes in neuronal, immune, and glial cell abundance, altered expression of multiple molecular pathways, and changes in vascular morphology. The...

Arvin Khoshboresh, Vijay Laxmi Roy, Mofida Abdelmageed et al. · bioRxiv · 0 citations

Open access Jul 2026

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan

A consolidated cellular-resolution transcriptomic atlas of human brain development from the onset of neurogenesis to adulthood is presented, covering ∼2.2 million cells from 156 donors across nine studies, and dynamic gene programs predictive of cell-type maturation are identified.

Sridevi Venkatesan, Patricia R. Nano, Jonathan M. Werner et al. · bioRxiv · 0 citations