Review
Open access
Nov 2026
EGFR-Mutated Small Cell Lung Cancer: Molecular Characterization and Clinical Implications of EGFR-TKIs
Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy defined by a number of genetic and molecular features, including near-universal TP53 and RB1 inactivation, MYC amplifications, Notch pathway disruption, and hyperactivated PI3K/AKT/mTOR signaling. The subtypes of SCLC, SCLC-A/N/P/I, are primarily...
D. Ampazis, Pinelopi Bosgana, E. Pavli et al.
· Genes · 0 citations