Jeroen Krijgsveld

Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability.

p53 plays a central role in the DNA damage response, inducing repair, cell-cycle arrest or apoptosis. Its loss is associated with replication stress and genomic instability. While several underlying mechanisms were suggested, the primary triggers of catastrophic genomic events like chromothripsis, a known driver of tum...

Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma

ProFormer: generalizable classification of single-cell and plasma proteomes using deep learning

Proteins are the main drivers of cell function and disease, making proteomics a powerful technique for biomarker discovery and defining cell identity. While current technologies can profile thousands of proteins and reach single-cell sensitivity, limited throughput restricts applications such as robust classification o...

Functional characterization of snoRNA-derived RNA (sdRNA) expression in healthy hematopoiesis and acute myeloid leukemia.

SDRNAs are introduced as standalone regulatory effector molecules in healthy hematopoiesis and AML and proposed and characterized NUDT21, an important regulator of alternative polyadenylation and oncogenic gene expression, as a downstream target of sd3'-SNORD78 in AML.